The 30-year Treasury punched above 5.10% intraday Friday, the highest level since George W. Bush was president, the same day Kevin Warsh was sworn in as Fed Chair on a mandate to cut rates. Cerebras closed its first week of public trading after the largest US tech IPO since Uber, the Senate Banking Committee advanced the CLARITY Act 15-9, and the naphtha shortage from the Iran war crossed into Japan's semiconductor supply chain.
The 30-year yield broke 5.10% intraday on the same day a new Fed chair was sworn in to cut rates, the cleanest possible illustration of the bond market voting against the Fed's mandate before the new chair could file his first vote. The Empire Manufacturing print at 19.6, a four-year high, removes the recession alibi for cutting and forces the FOMC to either deliver a cut into strength or hold and watch the curve do their work for them. Cerebras closed its public debut session at $311 and Fervo popped 33% the same week, both signals that the IPO window is wide open and the next S-1 wave is forming. ETH softened to roughly $2,194 even as tokenized stocks crossed $1.6 billion onchain, the asymmetry where short-term price is decoupling from the structural plumbing strengthening underneath.
The Vera C. Rubin Observatory completed an alert-system test on February 24 that produced 800,000 alerts in a single night. The full survey, beginning this summer, will generate 7 million alerts per night and 20 terabytes of data per night. First-light images already surfaced 1,500 new asteroids, including 19 superfast rotators. The fastest, 2025 MN45, is 700 meters across and rotates every 1.88 minutes, implying solid non-rubble-pile structure that suggests it is a fragment of a planetary core. Rubin saw the 3I/ATLAS interstellar comet ten days before the ATLAS network announced it. The instrument generates data faster than human pipelines can analyze, forcing an architectural shift to alert-driven, broker-mediated, ML-classified science. The bottleneck has moved from "can we see it" to "can we triage what we see."
Revolution Medicines' daraxonrasib roughly doubled median survival in metastatic pancreatic cancer to 13.2 months. RAS, present in 25% of human cancers and over 90% of pancreatic cancers, has been classified as "undruggable" for forty years because it lacks the binding pockets traditional drugs require. The "molecular glue" strategy creates artificial binding surfaces by recruiting the target protein into a complex with the cellular degradation machinery. The 13.2-month median survival fundamentally changes the oncology baseline for a disease where six-to-eleven-month survival was the standard for two decades. "Undruggable" was a description of which tools the field had. When the toolset changes, the universe of addressable targets expands by a factor not yet measured.
“It is not because things are difficult that we do not dare; it is because we do not dare that things are difficult.”
There is a particular flavor of paralysis that comes from staring at a hard thing and waiting to feel ready. The math of avoidance is brutal. Difficulty is not a property of the thing; it is a property of your relationship to the thing. The first call to the hard conversation. The first paragraph of the hard document. None of them go well. None of them have to. Today: pick the one thing on your list you have been most carefully not starting. Fifteen-minute timer. Start it. Do it badly. Break the spell.